Xi Dong, Qing Zeng, Chaoqun Zhan, Jinyong Chen, Zhong Chen, Yanqin Lin*. A simple data post-processing method for axial peaks free 2D PSYCHEDELIC NMR spectra. Journal of Magnetic Resonance, 325: 106938, 2021.
The paper is free accessible before April 15, 2021 at https://authors.elsevier.com/a/1cdyf3u0yjPozK.
Abstract:
Homonuclear scalar coupling plays an important role in the elucidation of molecular structure and dynamics. However, complex multiplets due to 1H–1H scalar coupling splittings complicate the assignment of peaks in overcrowded spectral regions. Although many methods focusing on disentangling couplings have been proposed in recent years, some defects like intense axial peaks and dispersive components still exist. Herein, a simple data post-processing method based on the interleaved acquisition mode PSYCHEDELIC (Pure Shift Yielded by CHirp Excitation to DELiver Individual Couplings) is designed to acquire absorption-mode 2D J spectrum while eradicating axial peaks. This approach provides a high resolution and pure absorptive spectrum, permitting unambiguous and accurate measurement of scalar coupling constants involving a given proton.
